Neugalin 150mg Capsule

Uses of Neugalin 150mg Capsule

It is used in adults to treat:

• Peripheral and central neuropathic pain
• Epilepsy (fits or seizures) in combination with other medicines
• Generalized Anxiety Disorder

How does Neugalin 150mg Capsule work?

• Controls seizures by reducing abnormal nerve cell activity in the brain.
• Acts as a specific analgesic for peripheral and central neuropathic pain.
• Blocks transmission of pain signals across the nervous system.
• Relieves anxiety by reducing the release of brain chemicals (GABA) causing abnormal mood stimulation and anxiety.

Side Effects of Neugalin 150mg Capsule

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and aberrant thinking

Quick Suggestions:

• Neugalin 150 should be taken as per the dose and duration prescribed by your doctor.
• It may cause sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
• It may cause blurring or loss of vision. Inform your doctor immediately if you notice any vision changes.
• Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
• Do not stop taking the medication suddenly without talking to your doctor as it may worsen your underlying condition.

Indication

• Management of neuropathic pain associated with diabetic peripheral neuropathy
• Management of post-herpetic neuralgia
• Adjunctive therapy for adult patients with partial-onset seizures
• Management of fibromyalgia
• Neuropathic pain associated with spinal cord injury

Pharmacology

• Derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
• Binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system
• Oral bioavailability ≥90%
• Renally excreted, with an elimination half-life of 6.3 hours in subjects with normal renal function

Dosage & Administration of Neugalin 150mg Capsule

Adult Dose:

Oral Neuropathic Pain, Postherpetic Neuralgia:

• Initial: 150 mg/day; may increase to 300 mg/day after 3-7 days.
• Max: 600 mg/day after a 7-day interval.
• All doses are administered in 2 or 3 divided doses.

Diabetic Peripheral Neuropathic Pain:

• Initial: 50 mg PO q8hr
• Maintenance: May increase to 100 mg PO q8hr within 1 week, not to exceed 300 mg/day

Adjunct in Partial Seizures:

• Adult: Initially, 150 mg/day; may increase to 300 mg/day after a week.
• Max: 600 mg/day.
• All doses are given in 2 or 3 divided doses.

Fibromyalgia:

• Initial: 150 mg/day; may increase to 300 mg/day after a week.
• Max: 450 mg/day if needed.
• All doses are administered in 2 or 3 divided doses.

Child Dose:

Safety and efficacy not established.

Renal Dose:

Renal Impairment: Haemodialysis:

• 25-100 mg immediately after each 4-hour hemodialysis session.

CrCl (ml/min) Dosage Recommendation:

• 30 to <60: 75 mg/day. Max: 300 mg/day. All doses are given in 2 or 3 divided doses.
• 15 to <30: Initially, 25-50 mg/day. Max: 150 mg/day. All doses are given as a single dose or in 2 divided doses.
• <15: Initially, 25 mg/day. Max: 75 mg/day. All doses are given as a single dose.

Interaction

• No significant interactions with other antiepileptic medicines or oral contraceptives
• Effects of ethanol and lorazepam may be potentiated by pregabalin

Contraindications

Known hypersensitivity to Pregabalin or its components

Pregnancy & Lactation

• Pregnancy category C; benefits should outweigh risks
• Use in nursing mothers only if benefits clearly outweigh risks

Precautions & Warnings

• Gradual tapering recommended to avoid withdrawal symptoms
• Monitoring of creatinine kinase levels advised
• Discontinue if myopathy is suspected or if creatinine kinase levels are elevated

Storage Conditions

• Store below 30°C, in a cool & dry place, protected from light & moisture
• Keep out of reach of children